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Serum beta defensin concentration in the first trimester is related to genotype, and is higher in women who develop PPROM and deliver before 34 weeks.
James C, Bajaj-Elliott M, Syngelaki A, Klein N, Nicolaides KH, Peebles D.
Arch Dis Child Fetal Neonatal Ed 2014;99 Suppl 1:A12. pdf -
First-trimester maternal serum matrix metalloproteinase-9 (MMP-9) and adverse pregnancy outcome.
Poon LC, Nekrasova E, Anastassopoulos P, Livanos P, Nicolaides KH.
Prenat Diagn 2009;29:553-9.