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Serum beta defensin concentration in the first trimester is related to genotype, and is higher in women who develop PPROM and deliver before 34 weeks.
James C, Bajaj-Elliott M, Syngelaki A, Klein N, Nicolaides KH, Peebles D.
Arch Dis Child Fetal Neonatal Ed 2014;99 Suppl 1:A12. pdf -
Urine albumin concentration and albumin-to-creatinine ratio at 11(+0) to 13(+6) weeks in the prediction of pre-eclampsia.
Poon LC, Kametas N, Bonino S, Vercellotti E, Nicolaides KH.
BJOG 2008;115:866-73.