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Early vaginal progesterone versus placebo in twin pregnancies for the prevention of spontaneous preterm birth: a randomized, double-blind trial.
Rehal A, Benkő Z, De Paco Matallana C, Syngelaki A, Janga D, Cicero S, Akolekar R, Singh M, Chaveeva P, Burgos J, Molina FS, Savvidou M, De La Calle M, Persico N, Quezada Rojas MS, Sau A, Greco E, O'Gorman N, Plasencia W, Pereira S, Jani JC, Valino N, Del Mar Gil M, Maclagan K, Wright A, Wright D, Nicolaides KH.
Am J Obstet Gynecol 2021;224:86.e1-86.e19. pdf -
Cervical pessary to prevent preterm birth in asymptomatic high-risk women: a systematic review and meta-analysis.
Conde-Agudelo A, Romero R, Nicolaides KH.
Am J Obstet Gynecol 2020;223:42-65.e2. pdf -
Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix: a meta-analysis of individual patient data.
Romero R, Conde-Agudelo A, Da Fonseca E, O'Brien JM, Cetingoz E, Creasy GW, Hassan SS, Nicolaides KH.
Am J Obstet Gynecol 2018;218:161-180. pdf -
Vaginal progesterone decreases preterm birth and neonatal morbidity and mortality in women with a twin gestation and a short cervix: an updated meta-analysis of individual patient data.
Romero R, Conde-Agudelo A, El-Refaie W, Rode L, Brizot ML, Cetingoz E, Serra V, Da Fonseca E, Abdelhafez MS, Tabor A, Perales A, Hassan SS, Nicolaides KH.
Ultrasound Obstet Gynecol 2017;49:303-14. pdf -
Vaginal progesterone decreases preterm birth <34 weeks of gestation in women with a singleton pregnancy and a short cervix: an updated meta-analysis including data from the OPPTIMUM study.
Romero R, Nicolaides KH, Conde-Agudelo A, O'Brien JM, Cetingoz E, Da Fonseca E, Creasy GW, Hassan SS.
Ultrasound Obstet Gynecol 2016;48:308-17. pdf -
A Randomized Trial of a Cervical Pessary to Prevent Preterm Singleton Birth.
Nicolaides KH, Syngelaki A, Poon LC, Picciarelli G, Tul N, Zamprakou A, Skyfta E, Parra-Cordero M, Palma-Dias R, Rodriguez Calvo J.
N Engl J Med 2016;374:1044-52. pdf -
Cervical pessary placement for prevention of preterm birth in unselected twin pregnancies: a randomized controlled trial.
Nicolaides KH, Syngelaki A, Poon LC, de Paco Matallana C, Plasencia W, Molina FS, Picciarelli G, Tul N, Celik E, Lau TK, Conturso R.
Am J Obstet Gynecol 2016;214:3.e1-9. pdf -
Effectiveness of progestogens to improve perinatal outcome in twin pregnancies: an individual participant data meta-analysis.
Schuit E, Stock S, Rode L, Rouse DJ, Lim AC, Norman JE, Nassar AH, Serra V, Combs CA, Vayssiere C, Aboulghar MM, Wood S, Atetingaz E, Briery CM, Fonseca EB, Worda K, Tabor A, Thom EA, Caritis SN, Awwad J, Usta IM, Perales A.
BJOG 2015;122:27-37. pdf -
Prevention of preterm delivery in twin gestations (PREDICT): A multicentre randomised placebo-controlled trial on the effect of vaginal micronised progesterone.
Rode L, Klein K, Nicolaides K, Krampl-Bettelheim E, Tabor A.
Ultrasound Obstet Gynecol 2011;38:272-80. -
Progesterone and the risk of preterm birth among women with a short cervix.
Fonseca EB, Celik E, Parra M, Singh M, Nicolaides KH.
N Engl J Med 2007;357:462-9.